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Authors
Kashiwagi, Yuto https://orcid.org/0009-0008-0387-9109
Tokuda, Tomoki https://orcid.org/0000-0001-6284-2113
Takahara, Yuji
Masaki, Yukiko
Sakai, Yuki https://orcid.org/0000-0003-2475-8548
Yoshimoto, Junichiro https://orcid.org/0000-0001-7995-0321
Yamashita, Ayumu https://orcid.org/0000-0003-3825-2919
Yoshioka, Toshinori
Ogawa, Koichi
Okada, Go
Okamoto, Yasumasa
Kawato, Mitsuo https://orcid.org/0000-0001-8185-1197
Yamashita, Okito
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Article History
Received: 28 June 2024
Revised: 30 July 2025
Accepted: 29 August 2025
First Online: 20 September 2025
Competing interests
: This study was supported by a collaboration fund of XNef, Inc. and Shionogi & Co., Ltd. Moreover, Y.S., T.Y., and M.K. are employees of XNef, Inc., and Y.K., Y.T., Y.M., and K.O., are employees of Shionogi & Co., Ltd.
: All participants provided written informed consent. All recruitment procedures and experimental protocols were approved by the respective institutional review boards (Advanced Telecommunications Research Institute International [approval numbers: 13-133, 14-133, 15-133, 16-133, 17-133, and 18-133], Hiroshima University [E-38], Kyoto Prefectural University of Medicine [RBMR-C-1098], Showa University [B-2014-019 and UMIN000016134], the University of Tokyo, Faculty of Medicine [3150], Kyoto University [C809 and R0027], and Yamaguchi University [H23-153 and H25-85]) and were conducted in accordance with the Declaration of Helsinki.
