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Authors
Lei, Hanyue Cecilia
Parker, Kyle E.
Kuo, Chao-Cheng
Yuede, Carla M.
McCall, Jordan G. https://orcid.org/0000-0001-8295-0664
Imai, Shin-ichiro https://orcid.org/0000-0003-3742-5777
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (AG037457, AG047902)
Tha Tanaka Fund at Washington University School of Medicine
McDonnell Center for Systems Neuroscience The Taylor Family Institute
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NS11789, NS11789)
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Article History
Received: 22 March 2024
Revised: 6 August 2025
Accepted: 5 September 2025
First Online: 16 September 2025
Competing interests
: S.I. declares no Competing Non-Financial Interests but the following Competing Financial Interests: S.I. receives a part of patent-licensing fees from MetroBiotech (USA) and the Institute for Research on Productive Aging (Japan) through Washington University. S.I. also serves as the President of the Institute for Research on Productive Aging (Japan) and a co-CEO of LongGen Bioscience (Japan). S.I.’s External Professional Activities (EPAs) have already been reported to, and a potential conflict of interest has been properly resolved through the Washington University Conflict of Interest Committee. The other authors have no Competing Financial or Non-Financial Interests.
: All animal procedures, including the ones on live animals, were approved by the Washington University Institutional Animal Care and Use Committee (WU IACUC) and were in accordance with National Institutes of Health guidelines. The animal protocol numbers approved by WU IACUC were 22-0007 and 24-0384 for the Imai lab and 20-0139 and 23-0261 for the McCall lab. This study did not involve any human subjects, and therefore no informed consent for publication is necessary.
