Millette, Amira
van Dijk, Milenna T.
Pokhvisneva, Irina
Li, Yifei
Thompson, Rory
Patel, Sachin https://orcid.org/0000-0002-4532-6659
Bagot, Rosemary C. https://orcid.org/0009-0005-5512-5294
Naray-Fejes-Toth, Aniko
Fejes-Toth, Geza
Silveira, Patricia Pelufo https://orcid.org/0000-0001-8626-2519
Turecki, Gustavo https://orcid.org/0000-0003-4075-2736
Lopez, Juan Pablo https://orcid.org/0000-0002-5812-4220
Anacker, Christoph https://orcid.org/0000-0002-9880-6760
Funding for this research was provided by:
Brain Behavior Research Foundation
Article History
Received: 2 April 2025
Revised: 26 August 2025
Accepted: 10 September 2025
First Online: 1 October 2025
Competing interests
: Dr. Anacker has received research funding from Sunovion Pharmaceuticals and consulting fees from Ono Pharmaceuticals. All other authors have no relevant conflicts to declare.
: All methods in this study were performed in accordance with the relevant guidelines and regulations. Animal care and all experimental procedures were approved by the Institutional Animal Care and Use Committee (IACUC) at the New York State Psychiatric Institute (Protocol #s 1698, 1637, 1545). Postmortem hippocampus tissue was obtained from the Douglas-Bell Canada Brain Bank with ethics approval from the Douglas Mental Health University Institute IRB (#ISUMD-13-39) and written informed consent from patients or family members, as appropriate. Secondary analyses of ABCD data for ePRS was approved by the Columbia University IRB (#AAAV0545).