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Authors
Shimono, Kohei
Kashida, Natsuko
Nishigori, Kantaro
Iwasaki, Tsuyoshi
Mizui, Ryo
Yamamuro, Kazuhiko https://orcid.org/0000-0002-4362-3262
Ishida, Rio
Toritsuka, Michihiro https://orcid.org/0000-0001-6891-4173
Takeda, Tsutomu
Tanakoshi, Hiroto
Nagata, Hidetaka https://orcid.org/0000-0003-4109-7657
Iwata, Nakao https://orcid.org/0000-0003-3189-6076
Makinodan, Manabu https://orcid.org/0000-0003-4339-9413
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Article History
Received: 30 March 2025
Revised: 22 September 2025
Accepted: 23 October 2025
First Online: 5 November 2025
Competing interests
: KS, KN, TI, and HN were employees of Sumitomo Pharma Co., Ltd., when the study was conducted. Dr. Makinodan received research support from Sumitomo Pharma. There is no other conflict of interest to report.
: All experimental procedures were conducted in accordance with the relevant guidelines and regulations. The clinical component of this study was reviewed and approved by the Ethics Committee of Nara Medical University (approval No. 1319). Written informed consent was obtained from all participants prior to their inclusion in the study. Animal experiments were reviewed and approved by the Institutional Animal Care and Use Committee of Sumitomo Pharma, Co., Ltd. (AN13526 and AN12879), and were performed in accordance with its institutional guidelines for the care and use of laboratory animals.
