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Authors
Cheliadinova, Uliana https://orcid.org/0009-0007-2308-4824
Sims, Steven https://orcid.org/0000-0002-1636-084X
Korkmaz, Funda
Vasilyeva, Darya
Laurencin, Victoria
Gimenez-Roig, Judit
Pevnev, Georgii
Burganova, Guzel https://orcid.org/0000-0002-7204-7268
Tumoglu, Zehra
Parte, Surabhi
Sultana, Farhath
Pallapati, Anusha R.
Rojekar, Satish
Macdonald, Anne
Hutchison, Susan
Soussan, Avi
Liu, Anchine
Wei, Yi
Moldavski, Ofer
Gumerova, Anisa
Zhou, Weibin
Barak, Orly
Goosens, Ki A. https://orcid.org/0000-0002-5246-2261
Ryu, Vitaly
Lizneva, Daria
Rosen, Clifford J.
Yuen, Tony https://orcid.org/0009-0001-6000-8827
Frolinger, Tal https://orcid.org/0000-0002-2066-6649
Zaidi, Mone https://orcid.org/0000-0001-5911-9522
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG074092)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U01 AG073148)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U19 AG060917)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (RF1 AG093773)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R61 AG094602)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG071870)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R61 AG094602)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (RF1 AG093773)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R61 AG094602)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG074092)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U01 AG073148)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01 AG071870)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R61 AG094602)
Hevolution Foundation
U.S. Department of Health & Human Services | National Institutes of Health (U19 AG060917)
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Article History
Received: 24 July 2025
Revised: 10 November 2025
Accepted: 2 December 2025
First Online: 16 December 2025
Competing interests
: MZ is an inventor on issued patents on inhibiting FSH for the prevention and treatment of osteoporosis and obesity (U.S. patents 8,435,948 and 11,034,761). MZ is also an inventor on a patent application on the composition and use of humanized monoclonal anti-FSH antibodies and is a co–inventor of a pending patent on the use of FSH as a target for preventing Alzheimer disease. MZ, SR and TY are co–inventors on a pending patent relating to the ultra–high formulation of an FSH-blocking antibody. DL, MZ and TY are co–inventors of a pending patent relating to LH and body composition. These patents are owned by Icahn School of Medicine at Mount Sinai (ISMMS), and the inventors and co–inventors would be recipients of royalties, per institutional policy. MZ also consults for several financial platforms, including Gerson Lehman Group and Guidepoint, on drugs for osteoporosis and genetic bone diseases. The other authors declare no competing interests.
: All methods were performed in accordance with the relevant guidelines and regulations. Animal handling and use were compliant with the National Institutes of Health’s Guide for the Care and Use of Laboratory Animals, and approved by the Icahn School of Medicine at Mount Sinai Institutional Animal Care and Use Committee (IACUC Approval # 2018-0047).
