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Authors
Krzeski, Joseph C. https://orcid.org/0000-0003-1116-7482
Mientjes, Edwin J. https://orcid.org/0000-0002-6700-9259
Judson, Matthew C. https://orcid.org/0000-0001-8659-1654
Dong, Guangkuo
Hipp, Rebecca I. https://orcid.org/0009-0008-2819-4405
Lien, Katelyn H.
Gu, Bin https://orcid.org/0000-0002-6846-5563
Philpot, Benjamin D. https://orcid.org/0000-0003-2746-9143
Elgersma, Ype https://orcid.org/0000-0002-3758-1297
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH120229)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS114086)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS129914)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS131615)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (F31NS139445)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS145518)
Simons Foundation (702556)
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Article History
Received: 17 October 2025
Revised: 17 November 2025
Accepted: 25 January 2026
First Online: 6 February 2026
Competing interests
: J.C.K., E.J.M., G.D., K.H.L., R.I.H., and B.G., declare no competing interests. M.C.J. and B.D.P. are inventors of a gene therapy for Angelman syndrome. This intellectual property has been filed, and a patent is pending (WO 2020/237130). B.D.P. is a consultant for Astellas Gene Therapies. These relationships have been disclosed to, and are under management by, the University of North Carolina at Chapel Hill. Y.E. is a consultant for Astellas Gene Therapies and for Innoser.
: All experiments in this study were strictly compliant and in accordance with the Institutional Animal Care and Use Committee (IACUC ID: 23-138.0 C) of the University of North Carolina at Chapel Hill and with the European Commission Council Directive 2010/63/EU (CCD approval AVD10100202216352) at Erasmus MC, Rotterdam. No human participants or data were used in this study.
