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Authors
Miyashita, Mitsuhiro https://orcid.org/0000-0002-7798-1834
Narita, Zui C. https://orcid.org/0000-0001-7022-2141
Devylder, Jordan
Yamasaki, Syudo https://orcid.org/0000-0002-9016-6404
Ando, Shuntaro https://orcid.org/0000-0003-1595-693X
Toriumi, Kazuya
Yamaguchi, Satoshi https://orcid.org/0000-0002-3988-1330
Nakanishi, Miharu https://orcid.org/0000-0001-6200-9279
Hosozawa, Mariko
Koike, Shinsuke https://orcid.org/0000-0002-3375-236X
Suzuki, Kazuhiro https://orcid.org/0000-0002-0038-4329
Baba, Kaori
Niimura, Junko
Nakajima, Naomi
Anglin, Deidre M.
Knowles, Gemma
Morgan, Craig
Richards, Marcus
Hiraiwa-Hasegawa, Mariko
Furukawa, Toshi A. https://orcid.org/0000-0003-2159-3776
Kasai, Kiyoto https://orcid.org/0000-0002-4443-4535
Nishida, Atsushi https://orcid.org/0000-0001-6451-7699
Arai, Makoto https://orcid.org/0000-0003-3400-9815
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Funding
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (JP21H05173)
MEXT | Japan Society for the Promotion of Science (JP23H05472)
MEXT | Japan Society for the Promotion of Science (JP24H00666)
MEXT | Japan Society for the Promotion of Science (JP20H03951)
MEXT | Japan Society for the Promotion of Science (23K27864)
MEXT | Japan Society for the Promotion of Science (22K14858)
MEXT | Japan Society for the Promotion of Science (JP20H01777)
MEXT | Japan Society for the Promotion of Science (23K07028)
MEXT | Japan Society for the Promotion of Science (22K07609)
MEXT | Japan Society for the Promotion of Science (JP24K16821)
MEXT | Japan Society for the Promotion of Science (JP24H00917)
MEXT | Japan Society for the Promotion of Science (JP21K10487)
MEXT | Japan Society for the Promotion of Science (JP24K02378)
MEXT | Japan Society for the Promotion of Science (JP19H03579)
MEXT | Japan Society for the Promotion of Science (JP24H00899)
MEXT | Japan Society for the Promotion of Science (JP23H03877)
MEXT | Japan Society for the Promotion of Science (JP22H05212)
MEXT | Japan Society for the Promotion of Science (JP21H05324)
MEXT | Japan Society for the Promotion of Science (JP20H03596)
MEXT | Japan Society for the Promotion of Science (JP21H05171)
MEXT | Japan Society for the Promotion of Science (JP21H05174)
MEXT | Japan Society for the Promotion of Science (23K27535)
MEXT | JST | Center of Innovation Program (JPMJPF2105)
MEXT | JST | Research Institute of Science and Technology for Society (JPMJRS24K1)
MEXT | Japan Science and Technology Agency (JPMJFR231Q)
Japan Agency for Medical Research and Development (JP24wm0625302)
Japan Agency for Medical Research and Development (JP23tm0524002)
Japan Agency for Medical Research and Development (JP19dm0207069)
Japan Agency for Medical Research and Development (JP18dm0307004)
Japan Agency for Medical Research and Development (JP19dm0207069)
Japan Agency for Medical Research and Development (JP18dm0307001)
Japan Agency for Medical Research and Development (JP18dm0307004)
he Moonshot Research and Development Program
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Article History
Received: 20 August 2025
Revised: 10 January 2026
Accepted: 18 February 2026
First Online: 27 February 2026
Competing interests
: Dr. Toshi A Furukawa reports personal fees from Boehringer-Ingelheim, Daiichi Sankyo, DT Axis, Micron, Shionogi, SONY and UpToDate, and a grant from DT Axis and Shionogi outside the submitted work. In addition, Toshi A Furukawa has a patent 7448125 and a pending patent 2022-082495 and has licensed intellectual properties for Kokoro-app to Mitsubishi-Tanabe. Dr. Kiyoto Kasai reports grants from Sumitomo and Otsuka; and personal fees from Sumitomo, Meiji-Seika, Ricoh, Fuji-film Wako, and Takeda outside the submitted work. The other authors declare no conflicts of interest.
