Mendes Duarte, Joana https://orcid.org/0000-0001-9272-4548
Janz, Philipp https://orcid.org/0000-0002-6472-2956
Bruns, Andreas
Gross, Simon
Bainier, Marie
Debilly, Sébastien
Schöppenthau, Stephanie
Bielser, Thomas
Künnecke, Basil https://orcid.org/0000-0001-5883-935X
Schulz, Jan M. https://orcid.org/0000-0003-1557-5352
Redondo, Roger L. https://orcid.org/0000-0002-3477-689X
Article History
Received: 3 June 2025
Revised: 6 February 2026
Accepted: 10 March 2026
First Online: 30 March 2026
Competing interests
: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. All the authors were employed by F. Hoffmann-La Roche (Roche) when the work was conducted. The funder provided support in the form of salaries and variable costs. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.
: All methods were performed in accordance with the relevant guidelines and regulations. All animal handling and experimental protocols were carried out with the permission of the Swiss Cantonal Veterinary Office and strictly adhered to Swiss federal regulations on animal protection, as well as the rules of the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) (BS-2857).