Feng, Yu
Jia, Ningning
Huang, Peng
Hu, Shaohua https://orcid.org/0000-0003-0570-670X
Yang, Sheng https://orcid.org/0000-0003-3657-8771
Article History
Received: 20 August 2025
Revised: 4 February 2026
Accepted: 10 March 2026
First Online: 17 March 2026
Competing interests
: The authors declare no competing interests.
: Ethical approval of UK Biobank study was granted by the National Health Service National Research Ethics Service (reference 11/NW/0382). Ethical approval of Chinese Longitudinal and Systematic Study of Bipolar Disorder was granted by the Medical Research Ethics Committee, and all participants provided written informed consent (Approval number: 2017-397). Written informed consent was secured from all participants and their legal guardians before they were enrolled in the study. It was a single-center study conducted at the First Affiliated Hospital, Zhejiang University School of Medicine (Clinical trial registration number: NCT05480150). All methods were performed in accordance with the relevant guidelines and regulations.