Lee, Younga Heather https://orcid.org/0000-0001-7517-6594
Zhang, Yingzhe https://orcid.org/0000-0001-5610-1159
Espinosa Dice, Ana Lucia
Li, Josephine H.
Tubbs, Justin D. https://orcid.org/0000-0002-6671-6816
Feng, Yen-Chen Anne https://orcid.org/0000-0003-2116-3645
Ge, Tian
Maihofer, Adam X.
Nievergelt, Caroline M. https://orcid.org/0000-0001-5766-8923
Smoller, Jordan W. https://orcid.org/0000-0002-0381-6334
Koenen, Karestan C. https://orcid.org/0000-0003-2978-7655
Roberts, Andrea L. https://orcid.org/0000-0001-5023-4399
Slopen, Natalie
Article History
Received: 24 June 2025
Revised: 27 January 2026
Accepted: 10 March 2026
First Online: 7 April 2026
Ethics declarations
: JWS is a member of the Scientific Advisory Board of Sensorium Therapeutics (with options), has received a consulting fee from Data Driven, Inc., and has received grant support from Biogen, Inc. KCK receives consulting fees from the US Department of Justice and Covington Burling LLP and has royalties from Guilford Press and Oxford University Press. All other authors report no biomedical financial interests or potential conflicts of interest.
: MGB Biobank participants are enrolled through a broad-based consent process by research coordinators at health system practices, public hospital locations, dual consent as part of collaborating studies, or electronically through Patient Gateway, the MGB patient portal. All participants provided informed consent prior to enrollment, agreeing to contribute a blood sample linked to their electronic health record. The seven-page consent form (available upon request) covers key provisions, including the use of samples for any type of research, recontact by Biobank staff as needed, and the return of medically actionable findings.