Tanaka, Rinako
Liao, Jingzhu
Liu, Yue
Zhu, Wenjun
Fukuzawa, Kisa
Kondo, Masamichi
Sawahata, Masahito
Mori, Daisuke https://orcid.org/0000-0002-9072-2546
Mouri, Akihiro https://orcid.org/0000-0003-3833-4041
Kubota, Hisayoshi
Tachibana, Daiki
Kobayashi, Yohei
Matsuzaki, Tetsuo https://orcid.org/0000-0002-3705-5473
Nagai, Taku https://orcid.org/0000-0001-5050-7748
Nabeshima, Toshitaka
Kaibuchi, Kozo
Ozaki, Norio https://orcid.org/0000-0002-7360-4898
Mizoguchi, Hiroyuki https://orcid.org/0000-0001-6993-4184
Yamada, Kiyofumi https://orcid.org/0000-0002-5280-5180
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP21wm0425007)
Japan Agency for Medical Research and Development (JP21wm0425017)
Japan Agency for Medical Research and Development (JP25wm0625518)
Japan Agency for Medical Research and Development (JP23ak0101215)
Japan Agency for Medical Research and Development (JP24ak0101221)
Japan Agency for Medical Research and Development (JP22gm1410011)
Japan Agency for Medical Research and Development (JP24zf0127011)
Japan Agency for Medical Research and Development (JP23gm1910005)
MEXT | Japan Society for the Promotion of Science (JP23H02669)
MEXT | Japan Society for the Promotion of Science (JP23K19425)
MEXT | Japan Society for the Promotion of Science (JP24K18365)
Takeda Science Foundation
SRF, Toyoaki Scholarship Foundation
Article History
Received: 30 September 2024
Revised: 12 February 2026
Accepted: 16 March 2026
First Online: 1 April 2026
Competing interests
: This study was funded in part by Sumitomo Pharma. Fasudil hydrochloride was received from Asahi Kasei Pharma Corp.
: All animal procedures were conducted in accordance with institutional and national guidelines and regulations. The study was approved by the Institutional Animal Care and Use Committee of Nagoya University (M230121-003, M240152-004, and M250107-001). No human participants were involved in this research.