Aagaard, Kristina
Pedersen, Casper-Emil T.
Horner, David
Eliasen, Anders
Brustad, Nicklas
Vinding, Rebecca
Talaei, Mohammad https://orcid.org/0000-0002-6901-3665
Shaheen, Seif O.
Rosenberg, Julie B. https://orcid.org/0000-0002-1320-3582
Stokholm, Jakob
Chawes, Bo
Rasmussen, Morten Arendt
Jepsen, Jens Richardt M.
Ebdrup, Bjørn H. https://orcid.org/0000-0002-2590-5055
Havdahl, Alexandra https://orcid.org/0000-0002-9268-0423
Hannigan, Laurie J. https://orcid.org/0000-0003-3123-5411
Bønnelykke, Klaus
Funding for this research was provided by:
Lundbeckfonden (Grant no R16-A1694)
Ministeriet Sundhed Forebyggelse (Grant no 903516)
Strategiske Forskningsråd (Grant no 0603-00280B)
Region Hovedstaden (-)
Novo Nordisk (grant agreement No. NNF21OC0068517)
EC | Horizon 2020 Framework Programme
Norges Forskningsråd (#274611, #336085)
Ministry of Health and Care Services | Helse Sør-Øst RHF (#2020022, #2019097, #2018059)
Ministry of Health and Care Services | Helse Sør-Øst RHF (#2022083, #2019097)
Article History
Received: 22 August 2025
Revised: 8 April 2026
Accepted: 30 April 2026
First Online: 25 May 2026
Competing interests
: All authors declare no potential, perceived, or real conflict of interest regarding the content of this manuscript. The funding agencies did not have any role in design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript. No pharmaceutical company was involved in the study. BE is part of the Advisory Board of Boehringer Ingelheim, Lundbeck Pharma A/S; and has received lecture fees from Boehringer Ingelheim, Otsuka Pharma Scandinavia AB, and Lundbeck Pharma A/S.
: We are aware of and comply with recognized codes of good research practice, including the Danish Code of Conduct for Research Integrity. We comply with national and international rules on the safety and rights of patients and healthy subjects, including Good Clinical Practice (GCP) as defined in the EU’s Directive on Good Clinical Practice, the International Conference on Harmonisation’s (ICH) good clinical practice guidelines and the Helsinki Declaration. Privacy is important to us which is why we follow national and international legislation on General Data Protection Regulation (GDPR), the Danish Act on Processing of Personal Data and the practice of the Danish Data Inspectorate.
: Data from the Norwegian Patient Registry has been used in this publication. The interpretation and reporting of these data are the sole responsibility of the authors, and no endorsement by the Norwegian Patient Registry is intended nor should be inferred.