Gaines-Smith, Maya C.
Silverman, Justin M.
Fiorillo, Michael
Younkin, Jason
Moore, Karah N.
Maltman, Jessica L.
de la Fuente Revenga, Mario
Wolstenholme, Jennifer T. https://orcid.org/0000-0003-3812-9312
Glennon, Richard A.
Dukat, Małgorzata
González-Maeso, Javier https://orcid.org/0000-0003-3105-3204
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R25 GM090084)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R25 GM090084)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R25 GM089614)
U.S. Department of Health & Human Services | National Institutes of Health (NIDA T32DA007027)
U.S. Department of Health & Human Services | National Institutes of Health (NIDA T32DA007027)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (T32 MH020030)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (T32 MH020030)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01 MH084894)
U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (P50AA022537)
Virginia Commonwealth University (VCU Breakthroughs Fund)
Virginia Commonwealth University (VCU Breakthroughs Fund)
Article History
Received: 29 July 2025
Revised: 12 December 2025
Accepted: 18 December 2025
First Online: 2 February 2026
Competing interests
: J.G.-M. has a consulting agreement with Boston Interactome , and has previously received research support from Terran Biosciences and Gonogo Solutions . J.G.-M. and M.D. have also received prior research support from the Noetic Fund . M.d.l.F.R. is a full-time employee of Axsome Therapeutics , which had no role in the funding, design, conduct, or interpretation of this study. The remaining authors declare no competing interests.