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Synaptic effects of interleukin-6 on human iPSC-derived dopaminergic neurons

Crossref DOI link: https://doi.org/10.1038/s41386-025-02320-y

Published Online: 2026-01-14

Published Print: 2026-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Huang, Yiqi https://orcid.org/0000-0001-9237-0102
Michalski, Christina https://orcid.org/0000-0001-9093-5325
Zhou, Ying

Xu, Chongchong

Niu, Weibo https://orcid.org/0000-0002-8395-3442
Lucido, Michael J. https://orcid.org/0000-0001-6489-4822
Wang, Jianjun

Feng, Yue https://orcid.org/0000-0002-7905-2182
Miller, Andrew H. https://orcid.org/0000-0001-8260-7997
Wen, Zhexing https://orcid.org/0000-0002-1518-3845
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R21MH132012)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH139822)

U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01MH121102)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R01NS110110)
License Information

Text and Data Mining valid from 2026-01-14

Version of Record valid from 2026-01-14
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Article History

Received: 22 May 2025

Revised: 14 December 2025

Accepted: 29 December 2025

First Online: 14 January 2026

Competing interests

: AHM is a paid consultant for Freedom Biosciences, Cerevel Therapeutics, and Sirtsei Pharmaceuticals, Inc.

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