Chang, Chia-Jung https://orcid.org/0000-0003-0977-8743
Huang, Po-Hsien https://orcid.org/0000-0002-2997-5181
Chen, Szu-Ying https://orcid.org/0000-0002-3998-5922
Su, Pei-Chia
Ding, Li-Yun
Hou, Ya-Chin
Hung, Miao-Neng
Chen, Kuan-Lin https://orcid.org/0000-0003-1387-1596
Wu, Ya-Na
Wu, Shang-Rung
Lin, Forn-Chia
Lu, Pei-Jung https://orcid.org/0000-0002-8143-5668
Wu, Hsin-Yi
Chen, Yu-Ju https://orcid.org/0000-0002-3178-6697
Chang, Chih-Han
Chang, Chih-Peng
Hwang, Daw-Yang
Wang, Yi-Ching https://orcid.org/0000-0002-7694-2067
Shan, Yan-Shen https://orcid.org/0000-0002-2457-5189
Article History
Received: 28 October 2024
Revised: 21 April 2025
Accepted: 30 April 2025
First Online: 29 May 2025
Competing interests
: The authors declare no competing interests.
: All methods were performed in accordance with relevant guidelines and regulations. The study protocol was approved by the Institutional Review Board of National Cheng Kung University Hospital under the approval numbers A-ER-111-541 and --/B-ER-101-209. Informed consent was obtained from all participants. All animal experiments were performed in compliance with the guidelines and adhered to ethical standards of the National Cheng Kung University (NCKU) Institutional Animal Care and Use Committee under institutional-approved animal experiment procedures (IACUC Permit Numbers: #104092, #105244, #106149, and #109248). The ARRIVE guidelines [] were consulted to ensure adequately reported animal studies. All mice used were maintained in the Laboratory Animal Center, National Cheng Kung University, ensuring humane treatment in accordance with vertebrate ethical regulations.