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Article History

Received: 18 May 2024

Revised: 11 June 2025

Accepted: 8 July 2025

First Online: 28 July 2025

Competing interests

: The authors declare no competing interests.

: All methods were performed following the relevant guidelines and regulations, including the Declaration of Helsinki for research involving human participants and Directive 2010/63/EU for the protection of animals used for scientific purposes. The study involving human participants was approved by the Comité Coordinador de Ética de la Investigación Biomédica de Andalucía, which issued a favorable opinion on April 10, 2024, for the project (Protocol version 1, dated 04/06/2023; IC version 7, dated 18/05/2021; internal code SICEIA-2024-000125; application code S2400018). Written informed consent was obtained from all participants before their inclusion in the study. The study also included research involving live vertebrates (mice, Mus musculus). It was authorized by the Dirección General de la Producción Agrícola y Ganadera of the Consejería de Agricultura, Pesca, Agua y Desarrollo Rural of the Junta de Andalucía. The corresponding ethics approval (reference number: 05/07/2023/58) was granted on July 6, 2023, for the project, classified as a Type II project involving mild to moderate procedures. The protocol was positively evaluated by the local Animal Ethics Committee and by the authorized body CEI de los Hospitales Universitarios Virgen Macarena - Virgen del Rocío de Sevilla. No identifiable images of human participants are included in this manuscript.