Crossmark

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility

Crossref DOI link: https://doi.org/10.1038/s41388-025-03545-3

Published Online: 2025-09-10

Published Print: 2025-10-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Dong, Xinrui https://orcid.org/0000-0002-4414-7288
Dai, Huijuan https://orcid.org/0000-0003-1225-8116
Yao, Linli

Lin, Yanping

Wang, Yaohui

Li, Ye

Zhang, Xueli https://orcid.org/0000-0001-8306-0639
Zhou, Liheng

Lu, Jinsong

Yin, Wenjin https://orcid.org/0000-0002-2129-7443
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82303865)

National Natural Science Foundation of China (82403115)
License Information

Text and Data Mining valid from 2025-09-10

Version of Record valid from 2025-09-10
More Information

Article History

Received: 6 January 2025

Revised: 11 July 2025

Accepted: 11 August 2025

First Online: 10 September 2025

Competing interests

: The authors declare no competing interests.

: All methods were performed in accordance with the relevant guidelines and regulations. All the human specimens were approved by the Ethics Committee of the Renji Hospital (permit number: RA-2023-130). All animal experiments were approved by the Animal Care Committee of East China Normal University (permit number: m20141203).

: Full tables of proteins identified from the protein mass spectrum in BT-20 control cells and EMC2-konckdown cells.

Document is current

Any future updates will be listed below