Wu, Zhiqiang https://orcid.org/0000-0002-1800-9527
Wang, Meixi
Dong, Xiaohan
Sun, Yanchen
Zhang, Lu
Tang, Mi
Jiang, Xiangli
Guo, Yu
Wang, Jing
Wang, Weiwei
Yuan, Zhiyong https://orcid.org/0000-0002-4745-6895
Mi, Zeyun
Funding for this research was provided by:
National Natural Science Foundation of China (81974364, 82373085, 82473240, 82170758)
the Natural Science Foundation and Science and Technology Project of Guangdong Province
Article History
Received: 30 April 2025
Revised: 8 October 2025
Accepted: 12 November 2025
First Online: 24 November 2025
Competing interests
: The authors declare no competing interests.
: This study was approved by the Institutional Review Board (IRB) of Tianjin Medical University Cancer Institute & Hospital and conducted in strict accordance with the Declaration of Helsinki. Written informed consent was obtained from each patient before enrollment. All animal experiments were approved by the Institutional Animal Care and Use Committee of Tianjin Medical University Cancer Institute and Hospital and conducted in accordance with the guidelines of the Institutional Animal Care and Use Committees of the NIH Guide. All methods were performed in accordance with the relevant guidelines and regulations.