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BRD4 orchestrates the metabolic-epigenetic regulation of GM-CSF expression and secretion to drive PD-L1⁺ macrophage-mediated immune evasion in triple-negative breast cancer

Crossref DOI link: https://doi.org/10.1038/s41388-026-03681-4

Published Online: 2026-02-14

Published Print: 2026-03-17

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Diao, Haizhou https://orcid.org/0009-0002-4166-720X
Chen, Jingxiong

Zhang, Yan

Hua, Hui

Dong, Menghao

Jin, Wei

Chen, Jian

Shan, Benjie

Cao, Yueyue

Han, Xinghua https://orcid.org/0000-0002-0632-6955
Yang, Xiuwei https://orcid.org/0000-0002-7636-2484
Pan, Yueyin https://orcid.org/0000-0003-0532-5368
Zhang, Jinguo https://orcid.org/0000-0001-9952-9307
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82472979)

National Natural Science Foundation of China (82172775)

National Natural Science Foundation of China (82203159)
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Text and Data Mining valid from 2026-02-14

Version of Record valid from 2026-02-14
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Article History

Received: 13 March 2025

Revised: 11 December 2025

Accepted: 25 January 2026

First Online: 14 February 2026

Competing interests

: The authors declare no competing interests.

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