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X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer

Crossref DOI link: https://doi.org/10.1038/s41388-026-03740-w

Published Online: 2026-04-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Gadad, Shrikanth S. https://orcid.org/0000-0003-0030-5472
Camacho, Cristel V. https://orcid.org/0000-0003-1723-579X
Gong, Xuan

Thornton, Micah

Malladi, Venkat S.

Nagari, Anusha

Sundaresan, Aishwarya

Nandu, Tulip

Koul, Sneh

Peng, Yan

Kraus, W. Lee https://orcid.org/0000-0002-8786-2986
Funding

Funding for this research was provided by:

American Cancer Society (RSG-22-170-01-RMC)

Cancer Prevention and Research Institute of Texas (RP190235)

Cancer Prevention and Research Institute of Texas (RR170020)

Cecil H. and Ida Green Center for Reproductive Biology Sciences Endowment to W.L.K.
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Article History

Received: 9 May 2025

Revised: 14 February 2026

Accepted: 12 March 2026

First Online: 1 April 2026

Ethics approval and consent to participate

: All animal experiments were performed in compliance with the Institutional Animal Care and Use Committee (IACUC) at the UT Southwestern Medical Center (APN 2015-101155). All procedures were carried out in accordance with institutional and national ethical guidelines for animal research. All human breast tissue samples were obtained from a commercial repository (TissueArray.com) as non-identifiable samples, therefore no informed consent was required.

: The authors declare no competing interests.

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