Fan, Xiaorui
Zhang, Ying
Yang, Zhengming
Tan, Tuan Zea https://orcid.org/0000-0001-6624-1593
Huang, Xingze
Zheng, Suya
Liu, Jiyang
Xie, Long
Tao, Ting https://orcid.org/0000-0003-1260-2351
Lee, Victor Kwanmin
Yu, Chao https://orcid.org/0000-0001-9798-2992
Koeffler, H. Phillip
Chen, Ye
Xu, Liang https://orcid.org/0000-0002-2700-4840
Funding for this research was provided by:
National Natural Science Foundation of China (32270746, 82203247)
National Natural Science Foundation of China (82203415)
Natural Science Foundation of Zhejiang Province (LZ23C060002)
Natural Science Foundation of Zhejiang Province (LZ24H160004)
Fundamental Research Funds for the Central Universities
Singapore Ministry of Education
Philanthropic donations from the Leiomyosarcoma Support and Direct Research Foundation
Article History
Received: 9 September 2025
Revised: 17 March 2026
Accepted: 9 April 2026
First Online: 16 April 2026
Competing interests
: HPK received a research grant from Karyopharm Therapeutics, Inc. The remaining authors declare that they have no conflicts of interest.
: All methods were performed following the relevant guidelines and regulations. Animal experiments were performed according to the approved protocols by the Zhejiang University Institutional Animal Care and Use Committee (Protocol ID: ZJU20210146).