Lundgren, Joseph G.
Flynn, Michael G.
Winkler, Ani R.
Rivera, Brianna N.
Tanabe, Lauren M.
Stemmer, Paul M. https://orcid.org/0000-0003-3315-9846
Chen, Li-Mei
Chai, Karl X.
List, Karin https://orcid.org/0000-0002-5847-5637
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA160565)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA222359)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (T32-CA009531)
U.S. Department of Health & Human Services | National Institutes of Health (5T32-GM142519-04)
U.S. Department of Health & Human Services | National Institutes of Health (P30ES036084)
U.S. Department of Health & Human Services | National Institutes of Health (P30CA022453)
U.S. Department of Health & Human Services | National Institutes of Health (S10OD030484)
Article History
Received: 12 January 2026
Revised: 26 February 2026
Accepted: 29 March 2026
First Online: 17 April 2026
Competing interests
: The authors declare no competing interests.
: All experimental methods, including cell line authentication, animal studies, and molecular analyses, were performed in accordance with relevant institutional, national, and international guidelines and regulations. Human tissue arrays were acquired by US Biomax/TissueArray.com. All tissue is collected under the highest ethical standards, with the donor being informed completely and with their consent, with the donors’ privacy protected. All human tissues are collected under HIPAA-approved protocols. The use of non-identifiable biospecimens in human tissue paraffin arrays and the collection of mouse tissues were performed according to the institutional guidelines by the Wayne State University Institutional Review Board Administration (HPR Determination number 2013-43) and the Institutional Animal Care & Use Committee (IACUC# A 06-12-11), respectively.