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Authors
Lima, Marco Aurelio B.
Menezes, Karla
Xerez, Denise R.
Côrtes, Bruno A. https://orcid.org/0000-0001-7970-514X
Menezes, João R. L.
Holanda, Gustavo S.
Silva, Adriana D.
Leite, Eliel S. https://orcid.org/0000-0002-6891-9529
Franco, Olavo B. https://orcid.org/0000-0003-4264-6048
Faria, Marco Aurélio A. M. de
Forte, Arthur de Freitas https://orcid.org/0000-0002-2735-287X
Abreu, Livia V. https://orcid.org/0009-0004-5704-8571
Lichtenberger, Renata C. L. https://orcid.org/0000-0002-5221-4241
Santana, Cíntia F.
Rosa, Maurilio
Graça-Souza, Aurélio V.
Jorge, Álvaro U. C.
Franzoi, Ana Cristina
Ferreira, Arthur S. https://orcid.org/0000-0001-7014-2002
Frajtag, Rose M.
Coelho‐Sampaio, Tatiana https://orcid.org/0000-0002-3020-9580
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Article History
Received: 8 April 2026
Revised: 11 June 2026
Accepted: 3 July 2026
First Online: 4 August 2026
Ethics
Competing interests: T.C.-S. reports a consulting relationship with Laboratório Cristália, initiated during the course of the study (after study initiation and prior to its completion). This relationship had no role in the study design, data collection, data analysis, data interpretation, or preparation of the manuscript. The remaining authors declare no competing interests.
Ethical approval: The study protocol was reviewed and approved by the Brazilian National Commission for Ethics in Research (CONEP; CAAE 3.474.884). The study was initiated in December 2016, prior to current requirements for prospective clinical trial registration, and retrospectively registered at the Brazilian Clinical Trials Registry (ReBEC), which is part of the World Health Organization International Clinical Trials Registry Platform (ICTRP-WHO). The ReBEC identifier code is RBR-9dfvgp, and the trial received the Universal Trial Number (UTN) U1111-1144-5390. Written informed consent was obtained from all participants after the nature and possible consequences of the study had been explained.
Patient consent for images or information used in a manuscript: All participants provided written informed consent for publication of anonymized data. No identifying information is disclosed, and all images were processed, including blurring where appropriate, to ensure participant confidentiality.
