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Article History
Received: 4 March 2021
Revised: 2 June 2021
Accepted: 21 June 2021
First Online: 17 July 2021
Funding
: This work was funded by the German Research Foundation (DFG CRC 1193, subprojects B01, C01, C04, C05, C07, Z03), the Stiftung Rheinland-Pfalz für Innovation (MARP program, number 961-386261/1080), the Ministry of Science of the state of Rhineland-Palatinate (DRZ program), and the European Union’s Horizon 2020 research and innovation program (grant agreements numbers 777084, 667302, and 728018). Open Access funding enabled and organized by Projekt DEAL.
: The authors declare no competing interests.
: The manuscript does not contain clinical studies or patient data. All procedures were approved by the respective Ethical Committees in Mainz (registration number: 837.105.16(10424), Amendment 2018-13545_3) and Frankfurt (registration number: 244/16; Amendment: 20-611) complied with the Declaration of Helsinki (latest version) and written informed consent was obtained from all participants.