Walker, Rosie M. http://orcid.org/0000-0002-1060-4479
Chong, Michael
Perrot, Nicolas http://orcid.org/0000-0002-2395-2333
Pigeyre, Marie http://orcid.org/0000-0003-2984-8366
Gadd, Danni A. http://orcid.org/0000-0001-6398-5407
Stolicyn, Aleks http://orcid.org/0000-0002-1147-7539
Shi, Liu
Campbell, Archie http://orcid.org/0000-0003-0198-5078
Shen, Xueyi http://orcid.org/0000-0002-0538-4774
Whalley, Heather C. http://orcid.org/0000-0002-4505-8869
Nevado-Holgado, Alejo http://orcid.org/0000-0001-9276-2720
McIntosh, Andrew M. http://orcid.org/0000-0002-0198-4588
Heitmeier, Stefan http://orcid.org/0000-0003-2108-8286
Rangarajan, Sumathy
O’Donnell, Martin
Smith, Eric E. http://orcid.org/0000-0003-3956-1668
Yusuf, Salim
Whiteley, William N. http://orcid.org/0000-0002-4816-8991
Paré, Guillaume http://orcid.org/0000-0002-6795-4760
Funding for this research was provided by:
Gouvernement du Canada | Canadian Institutes of Health Research (G-18–0022359)
Heart and Stroke Foundation of Canada (399497)
Wellcome Trust (108890/Z/15/Z, 204804/Z/16/Z, 104036/Z/14/Z, 220857/Z/20/Z, 216767/Z/19/Z)
Lister Institute of Preventive Medicine (173096)
RCUK | Medical Research Council (MC_PC_17215, MR/L023784/2, MR/L023784/2, MC_PC_17209)
Article History
Received: 18 September 2023
Revised: 17 April 2024
Accepted: 23 April 2024
First Online: 18 May 2024
Competing interests
: MC is supported by a Canadian Institute of Health Research doctoral award and has received consulting fees from Bayer AG. MP is supported by the EJ Moran Campbell Internal Career Research Award from McMaster University. DAG is a part-time employee of Optima partners, a health data consultancy based at the Bayes centre, The University of Edinburgh. SH is an employee of Bayer AG. AMM has previously received speaker’s fees from Illumina and Janssen and research grant funding from The Sackler Trust. SY is supported by the Heart and Stroke Foundation/Marion W Burke Chair in Cardiovascular Disease. GP is supported by the CISCO Professorship in Integrated Health Systems. The other authors declare no competing interests.
: PURE study: All centres contributing to PURE were required to obtain approval from their respective ethics committees (Institutional Review Boards). Participant data is confidential and only authorized individuals can access study-related documents. The participants’ identities are protected in documents transmitted to the Coordinating Office, as well as biomarker and genetic data. Participants provided informed consent to obtain baseline information, and to collect and store genetic and other biological specimens.