Dawson, Kristin L.
Carangan, Athena May Jean M.
Klunder, Jessica
Carreras-Gallo, Natalia
Sehgal, Raghav
Megilligan, Samantha
Askins, Benjamin C.
Perkins, Nicole
Mendez, Tavis L.
Smith, Ryan M.
Dawson, Matthew S.
Mallin, Michael P.
Higgins-Chen, Albert T. https://orcid.org/0000-0003-2904-2741
Dwaraka, Varun B. https://orcid.org/0000-0001-9033-3092
Article History
Received: 9 February 2025
Revised: 6 September 2025
Accepted: 2 October 2025
First Online: 31 October 2025
Competing interests
: KLD and SM are employed with Expedition Mental Health. AC, NCG, TLM, RMS, MSD, MPM, and VBD are employed with TruDiagnostic Inc. BCA is employed with Wild Health. ATH and RS have received consulting fees from TruDiagnostic Inc. for work unrelated to the present manuscript, and are named as inventors on a patent for the SystemsAge scores.
: All study procedures were performed in accordance with relevant guidelines and regulations (including the Declaration of Helsinki and ICH-GCP). The protocol was reviewed and approved by the The Institutional Review Board of INSTITUTE OF REGENERATIVE AND CELLULAR MEDICINE gave ethical approval for this work (Protocol: Tru-012-2022v2; Approval/Registration: IRCM-2022-369). Informed consent was obtained from all participants prior to any study procedures. No animal experiments were performed.
: This article does not include identifiable images or other personal data from human participants; therefore, consent for publication is not applicable.