Zhou, Yesheng
Liu, Si
Xie, Sian
Zhang, Qian
Zhang, Shutian
Zhu, Shengtao
Wu, Shanshan https://orcid.org/0000-0001-9791-8093
Funding for this research was provided by:
National Natural Science Foundation of China (82570631)
Beijing Nova Program (20230484349)
Beijing Nova Program (20230484349)
National Key Research and Development Program of China
National Key Research and Development Program of China
Article History
Received: 2 June 2025
Revised: 11 December 2025
Accepted: 20 January 2026
First Online: 28 January 2026
Competing interests
: The authors declare no competing interests.
: The UK Biobank study was approved by the North West Multicenter Research Ethical Committee (21/NW/0157), and all participants or their proxy respondents provided written informed consent. All methods were performed in accordance with the relevant guidelines and regulations.
: Not applicable.
: Patients and the public were not involved in the design, conduct, reporting or dissemination plans of this research.