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Authors
Balan, Irina
Pearson, Cecilia Isabel Sousa
Krohn, Holly
O’Buckley, Todd K. https://orcid.org/0000-0001-8723-734X
Xia, Kai https://orcid.org/0000-0001-8254-4092
Meltzer-Brody, Samantha
Morrow, A. Leslie
Patterson, Riah
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Funding
Funding for this research was provided by:
This work was supported by a grant from the Foundation of Hope, Raleigh, NC, USA.
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Article History
Received: 9 June 2025
Revised: 12 December 2025
Accepted: 20 January 2026
First Online: 31 January 2026
Competing interests
: ALM and IB declare a U.S. provisional patent on the anti-inflammatory effects of allopregnanolone and related steroids. ALM and SMB have previously received research funding from Sage Therapeutics for other projects. SMB has received consulting fees from Ancora Bio, Modern Health and Web MD. The authors declare no other potential conflicts of interest.
: This study was approved by the Institutional Review Board (IRB) at the University of North Carolina (UNC) at Chapel Hill, North Carolina, USA, IRB# 23-1288. Written informed consent was obtained from all participants. All clinical procedures and experimental methods were performed in accordance with the relevant guidelines and regulations.
