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Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation

Crossref DOI link: https://doi.org/10.1038/s41398-026-03862-5

Published Online: 2026-03-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Lu, Zhenbin

Shi, Wenhan https://orcid.org/0009-0007-4078-8452
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Text and Data Mining valid from 2026-03-30

Version of Record valid from 2026-03-31
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Article History

Received: 19 February 2025

Revised: 15 December 2025

Accepted: 28 January 2026

First Online: 30 March 2026

Competing interests

: The authors declare that they have no competing interests that could have appeared to influence the work reported in this paper.

: All methods were performed in accordance with the relevant guidelines and regulations, including the declaration of Helsinki for human subjects and the National Institutes of Health (NIH) guidelines of animal care. This study was approved by the Ethics Committee of the Affiliated Yueqing Hospital of Wenzhou Medical University (ethics proposal: YQYY202500078). Written informed consent was obtained from all MDD patients and volunteers prior to their enrollment. All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) at the Wenzhou Medical University.

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