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Authors
Seki, Tomoteru https://orcid.org/0000-0003-2593-7118
Nishitani, Shota
Nishizawa, Yoshitaka
Yamanishi, Kyosuke
Shimura, Akiyoshi
Nishiguchi, Tsuyoshi
Ishii, Takaya https://orcid.org/0000-0001-6026-8664
Aoyama, Bun
Santiago, Therese Anne
Phuong, Nathan James https://orcid.org/0009-0003-8374-782X
Gorantla, Nipun
Nguyen, Hieu Dinh
Takeda, Ryo
Kameoka, Takashi
Inoue, Takeshi https://orcid.org/0000-0001-5248-1289
Sugiyama, Daisuke
Ueda, Kenichi
Yamanashi, Takehiko https://orcid.org/0000-0002-3881-8997
Shinozaki, Gen https://orcid.org/0000-0001-6129-2789
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01 MH119165)
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01 AG084710)
Dainippon Sumitomo Pharma
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Article History
Received: 10 September 2025
Revised: 5 April 2026
Accepted: 30 April 2026
First Online: 16 May 2026
Competing interests
: G.S. is a co-founder of Delight Health Inc and has pending patents: “Non-invasive device for predicting and screening delirium,” PCT application no. PCT/US2016/064937 and US provisional patent no. 62/263,325; “Prediction of patient outcomes with a novel electroencephalography device,” US provisional patent no. 62/829,411; and “Epigenetic Biomarker of Delirium Risk,” PCT application no. PCT/US19/51276 and US provisional patent no. 62/731,599. T.I. is employed by Sumitomo Pharma Co., Ltd, and currently affiliated with RACTHERA Co., Ltd. The other authors declare no actual or potential conflicts of interest associated with this study.
: All methods were performed in accordance with the relevant guidelines and regulations. This study was approved by the Institutional Review Boards of Stanford University (study approval no.: 63791) and Kameda Medical Center (study approval no.: 19-171-230331). Written informed consent was obtained from all participants.
