Crossmark

Cryo-EM structures of GPR75 reveal an occluded orthosteric pocket challenging conventional drug discovery paradigms for an anti-obesity target

Published Online: 2026-01-16

Authors

Zhu, Zi-ning

You, Chong-zhao

Yuan, Qing-ning

Xu, Jiu-yin

Gu, Zong-yue

Huang, Zheng

Liu, Miao

Shan, Bei

Wang, James Jiqi

Hu, Wen

Wang, Kai

Yin, Wan-chao

Xu, You-wei

Xu, H. Eric

Wu, Can-rong
License Information

Text and Data Mining valid from 2026-01-16

Version of Record valid from 2026-01-16
More Information

Article History

Received: 26 October 2025

Accepted: 24 November 2025

First Online: 16 January 2026

Competing interests

: ZH, ML, and BS are employed by BioFront Therapeutics. HEX is one of the Associate Editors of APS and was not involved in the peer review or the decision making of the article. The authors declare no other competing interests.

Document is current