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Authors
Toscan, Cara E.
McCalmont, Hannah
Ashoorzadeh, Amir
Lin, Xiaojing
Fu, Zhe
Doculara, Louise
Kosasih, Hansen J. https://orcid.org/0000-0002-0428-6195
Cadiz, Roxanne
Zhou, Anthony
Williams, Sarah
Evans, Kathryn
Khalili, Faezeh
Cai, Ruilin
Yeats, Kristy L.
Gifford, Andrew J.
Pickford, Russell
Mayoh, Chelsea https://orcid.org/0000-0002-6398-3046
Xie, Jinhan
Henderson, Michelle J. https://orcid.org/0000-0003-2741-3852
Trahair, Toby N. https://orcid.org/0000-0002-3295-228X
Patterson, Adam V. https://orcid.org/0000-0001-5138-1227
Smaill, Jeff B.
de Bock, Charles E. https://orcid.org/0000-0001-5182-8535
Lock, Richard B. https://orcid.org/0000-0002-3436-9071
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Funding
Funding for this research was provided by:
Leukemia and Lymphoma Society (TRP 6648-23)
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Article History
Received: 8 September 2024
Revised: 20 October 2024
Accepted: 24 October 2024
First Online: 6 November 2024
Competing interests
: AVP and JBS are inventors on patents related to ACHM-025 (US11661404B2, EP3774743B1, CN111918864B) assigned to Achilles Medical Ltd., a privately-held company. AVP and JBS are part-owners of Achilles Medical Ltd. and stand to benefit financially from commercial development of ACHM-025. All other authors declare no competing interests.
: All methods used in this study were performed in accordance with the relevant guidelines and regulations. The PDXs used in this study were previously established under approval from the Sydney Children’s Hospitals Network and the UNSW Sydney Human Research Ethics Committees (HREC10/114, HC10442 and 2019/ETH10580) and the UNSW Sydney Animal Care and Ethics Committee (ACECs 16/168B, 17/101B, 19/82B, 19/136B, 20/119B, 22/58B, 22/152B and 23/82B). The RNA-sequencing data derived from primary patient samples used in this study were under approval from the Sydney Children’s Hospitals Network and the UNSW Sydney Human Research Ethics Committees (LNR/14/SCH/497, 2109/ETH10480 and 2022/ETH01232). Informed consent was obtained from all participants. No identifiable images from human research participants were used in this study.
