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Single-cell transcriptomic analysis identifies systemic immunosuppressive myeloid cells and local monocytes/macrophages as key regulators in polytrauma-induced immune dysregulation

Crossref DOI link: https://doi.org/10.1038/s41413-025-00444-x

Published Online: 2025-07-07

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Maniar, Drishti

Keenum, M. Cole

Vantucci, Casey E.

Guyer, Tyler

Chatterjee, Paramita https://orcid.org/0000-0001-9761-2289
Leguineche, Kelly

Cheung, Kaitlyn

Guldberg, Robert E.

Roy, Krishnendu https://orcid.org/0000-0002-9972-0950
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | National Institutes of Health (GR00008150)

U.S. Department of Health & Human Services | National Institutes of Health (GR00008150)
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Text and Data Mining valid from 2025-07-07

Version of Record valid from 2025-07-07
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Article History

Received: 8 August 2024

Revised: 30 April 2025

Accepted: 22 May 2025

First Online: 7 July 2025

Competing interests

: The authors declare no competing interests.

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