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Evaluation of multi-ion releasing composite and conventional restorative materials on post-irradiated head and neck cancer patients: four case reports

Crossref DOI link: https://doi.org/10.1038/s41415-025-9344-5

Published Online: 2026-03-13

Published Print: 2026-03-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Gomes, Mauricio Neves

Gomes-Silva, Wagner

de Araújo, Maico Dutra

DeVito-Moraes, André Guaraci

Brandão, Thais Bianca
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Article History

Received: 25 June 2025

Revised: 17 September 2025

Accepted: 29 September 2025

First Online: 13 March 2026

Ethics declaration

: The authors have no relevant financial or non-financial interests to disclose. Clinical Trial Registration: Clinical evaluation of fluoride-releasing dental materials and composite resin in the Restorative Treatment of Radiation-Related Caries in Patients With Cancer Head and neck: 12-month. National Health Council (protocol number 3,952,162). The protocol for the present investigation was approved by the local ethics committee for human studies (Approved on November 01,2019. Núcleo de pesquisa do INSTITUTO DO CÂNCER DO ESTADO DE SÂO PAULO. Approved on April 03,2020. HOSPITAL DAS CLÍNICAS DA FACULDADE DE MEDICINA DA UNIVERSIDADE DE SÃO PAULO - HCFMUSP). The investigation was conducted according to the principles outlined in the declaration of Helsinki, and written informed consent was obtained from the participants for participation and for potential publication.

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