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Article History
Received: 10 October 2017
Revised: 4 January 2018
Accepted: 4 January 2018
First Online: 9 March 2018
Competing interests
: J.P.N. reports a consulting or advisory role for Boehringer Ingelheim Pharma GmbH & Co. KG; Novartis Pharma AG; KAEL GemVax and Astellas. Research Funding from Taiho Pharma (Japan), PI, paid to Institution; KAEL GemVax (Korea), PI, paid to Institution; AstraZeneca, PI, paid to Institution; Pharma Nord, PI, paid to Institution. Travel expenses from NUCANA, Amgen and Mylan. B.G. reports a consulting and advisory role for Pledpharma AB and Isofol AB. M.D. reports a consulting and advisory role for socar research.com and travel expenses from Imotech. M.M.L. reports consulting and advisory role for Solvay, Axcan, Abbvie, Abbott, Mylan, Nordmark, AstraZeneca, Centogene, Roche, ISIS, Ionis and KMG Kliniken. Travel expenses from Falk Foundation, Roche, Abbott and Abbvie, Roche, Menarini, Abbott, Abbvie, Mylan and Nordmark. Research Funding from Deutsche Forschungsgemeinschaft (DFG), Deutsche Krebshilfe/lvlildred Scheel Stiftung, Krupp Foundation, German Federal Ministry of Education and Research (BMBF), European Union (FP7, EFRE, ESF and Horizon 20120), the State Ministy of Education and Research Mecklenburg-Vorpommern, State Minisüry of Economics MV. J.R.M. reports consulting and advisory role for Pfizer, Stock or other ownership from Pacylex Pharmaceuticals Inc. and patent or intellectual property from Pacylex Pharmaceutical Inc. J.M. reports consulting or advisory role for Metonomics Health. Research funding from AstraZeneca, patent or intellectual property from Metanomics Health, Honoraria from Boehringer Ingelheim and Falk Foundation and Travel Expenses from Falk and Celgene. J.S. reports a consulting or advisory role for Amgen. W.G. reports travel expenses from Nucana Biomed. N.C.T. reports travel expenses from Roche and Honoraria from Amgen, Roche and Shire. N.O.E. reports research funding from NUCANA. D.G. reports research funding from Celgene. D.H.P. reports research funding from Nucana Biomed and Honoraria from Bayer, Nucana Biomed, Sictex, Celgene and Baxalta. A.G.S. reports Speakers’ Bureau from Amgen and Honoraria from Amgen, Sanofi, Roche, Lilly, Leo and Celgene. The remaining authors declare no competing interests.