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Article History

Received: 26 April 2018

Revised: 11 August 2018

Accepted: 31 August 2018

First Online: 2 November 2018

Competing interests

: The authors declare no competing interests.

: The use of hPSCs and vertebrate animals in this study was approved by the institutional committees. The detailed information was provided under <b>Materials and Methods</b>.

: All authors have read and approved the manuscript, its content, and its publication.

: Upon appropriate request with the completion of interinstitutional material transferring agreements/licensing, the cell clones and novel compounds used in this study could be made available for other researchers’ use. The data of global gene expression profiling have been deposited in an open access database. The detailed information was provided under <b>Materials and Methods</b>.

: This work is supported by the UNTHSC Start-up Fund for Stem Cell Laboratory and Faculty Pilot Grant FY15 (RI6182) to Y.C.W, Start-up Fund for Medicinal Chemistry Laboratory to K.A.E., and Start-up Fund for Computational Chemistry Laboratory to J.L. V.J.T.L. is supported by the NIH NRSA Institutional Predoctoral Training Grant (T32 AG020494), and predoctoral fellowships from the American Medical Association (AMA) Foundation and the Cancer Prevention Research Institute of Texas (CPRIT; RP170301). Y.Y.H. and P.H. are supported by the Ovarian Cancer Research Foundation.