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Article History

Received: 16 January 2019

Revised: 28 June 2019

Accepted: 4 July 2019

First Online: 29 July 2019

Competing interests

: J.C. has received honoraria, consulting and/or advisory fees, and travel and accommodations expenses from Amgen; research funding from Amgen, Iovance, and Bristol-Myers Squibb; and has received reimbursement for service on a scientific advisory panel for Replimune. I.P. has received honoraria, consulting and/or advisory fees, and travel and accommodations expenses from Amgen. F.C. has received consulting fees from Amgen through a consulting agreement that ended in 2018, and institutional research funding from Amgen and Novartis. M.M. has served on the GIST advisory board for Blueprint Solutions and on an advisory board for Amgen. A.H. has received research funding, consulting fees, and honoraria from Novartis, Amgen, Bristol-Myers Squibb, MSD/Merck, Pierre Fabre, Provectus, and Roche; research funding and consulting fees from Merck Serono, Philogen, and Regeneron; consulting fees and speakers’ honoraria from Sanofi-Aventis, and consulting fees from OncoSec and Philogen. L.C. and A.S. are employees of and own stock in Amgen. C.G. has received honoraria and consulting and/or advisory fees from Amgen, Bristol-Myers Squibb, Merck Sharpe & Dohme, Novartis, and Roche; research funding from Bristol-Myers Squibb, Novartis, and Roche; and travel and accommodations expenses from Amgen, Bristol-Myers Squibb, Merck Sharpe & Dohme, and Novartis. P.S. has nothing to disclose. J.M. has received honoraria and consulting and/or advisory fees from Boehringer Ingelheim, EMD Serono, Pfizer, Merck, and Amgen; research funding from Amgen, Novartis, Merck, Polynoma, AstraZeneca, Immunocore, Macrogenics, and Incyte; and travel and accommodation expenses from Merck, EMD Serono, and Boehringer Ingelheim.

: All patients provided written informed consent; study procedures were approved by the institutional review boards/ethics committees at each site (for a listing of the names for all participating sites see Table S3). The study was performed in accordance with the Declaration of Helsinki.

: This study was sponsored by Amgen Inc.

: Patient consent was obtained for all images.

: Qualified researchers may request data from Amgen clinical studies. Complete details are available at the following: ExternalRef removed.