Solis-Hernandez, Mª Pilar
Fernandez del Valle, Ana
Carmona-Bayonas, Alberto
Garcia-Carbonero, Rocio
Custodio, Ana
Benavent, Marta
Alonso Gordoa, Teresa
Nuñez-Valdovino, Bárbara
Sanchez Canovas, Manuel
Matos, Ignacio
Alonso, Vicente
Lopez, Carlos
Viudez, Antonio
Izquierdo, Marta
Calvo-Temprano, David
Grande, Enrique
Capdevila, Jaume
Jimenez-Fonseca, Paula
Funding for this research was provided by:
Pfizer Inc. | Pfizer Foundation (Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable, Not applicable)
Article History
Received: 16 May 2019
Accepted: 9 August 2019
First Online: 3 September 2019
Competing interests
: M.P.S.H. declares travel grants from and travel accommodations from Amgen, Astellas, Astrazeneca, BMS, Ipsen, Novartis Sanofi, Pfizer, PharmaMar and Roche. Financial support for educational programs from BMS, MSD, Ipsen, Novartis Sanofi, Pfizer, PharmaMar and Roche. Honoraria for meetings and/or lectures from Astrazeneca, Pfizer and Roche. A.C.B. declares travel grants from Ipsen, Roche and Novartis and consulting/advisory role for Roche, Rovi, LeoPharma, Pfizer, Esteve all outside of the scope of this work. R.G.C. declares having provided scientific advice and/or received honoraria from AAA, Amgen, Bayer, Ipsen, Lilly, Merck, MSD, Novartis, PharmaMar, Pfizer, Roche and Sanofi-Aventis, and has received research support from Pfizer and BMS.T.A.G. declares advisory role, travel grants and research funding from IPSEN, Novartis, Roche, BMS, Pfizer, Sanofi, Janssen, Astellas, Astrazeneca. B.N.V. has received honoraria for advisory role from Novartis, declares travel grants and accommodations for educational programs from Tecnopharma, Pfizer, Bayer, Sanofi, MSD. M.S.C. has received honoraria for advisory role from KyowaKirin, research funding from Leo Pharma, travel accommodations from Sanofi, MSD, Esteve, Amgen, Servier, Angelini, financial support for educational programs from Angelini, Sanofi, Rovi. V.A. declares advisory role from Amgen, Roche, Merck, Servier, Sanofi, Bayer, Ipsen, Novartis; travel accommodations from Roche, Merck, Novartis, Ipsen, Sanofi; personal fees from Amgen, Roche, Merck, Servier, Sanofi, Bayer, Ipsen, Novartis, AAA and non-financial support from Roche, Merck, Novartis, Ipsen, Sanofi. C.L. has received honoraria from Roche, Merck, Sanofi, Pfizer, Eisai, Ipsen, Bayer; consulting or advisory role from Amgen, Roche, Sanofi, Merck, Servier, Pfizer, Ipsen, Bayer, Eisai; research funding from Amgen, Roche, Merck, Sanofi, Bayer, Ipsen, Eisai, Celgene and travel accommodations from Roche, Pfizer, Merck. Servier, Amgen, and Ipsen. E.G. has received honoraria for ad boards, meetings and/or lectures from Pfizer, BMS, IPSEN, Roche, Eisai, Eusa Pharma, MSD, Sanofi, AAA, Novartis, Pierre Fabre, Lexicon, and Celgene and has received unrestricted research grants from Pfizer, Astra Zeneca, MTEM/Threshold, Roche, IPSEN and Lexicon. J.C. has received honoraria for scientific consultancy role from Novartis, Pfizer, Ipsen, Exelixis, Bayer, Eisai, AAA, Amgen, Sanofi, and Merck and research support from Eisai, Novartis, Ipsen, Astrazeneca, Pfizer, and AAA. P.J.F. declares travel grants from Ipsen and consulting/advisory role for Roche, Celgene, Bristol, Mylan, Rovi, LeoPharma, all outside of the scope of this work. The remaining authors declare no competing interests.
: All procedures followed were in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. All institutional ethics committees that have approved this study are listed in Supplementary Table InternalRef removed. Informed consent was obtained from all patients before being included in the study.
: This study has been funded by a restricted grant from Pfizer, S.A. This entity has not contributed to the design of the study, analyses, interpretation of results, drafting of the document or to the decision regarding publication.
: All the data generated or analysed in this study are included in the manuscript or the supplementary information.