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Article History

Received: 3 May 2019

Revised: 11 August 2019

Accepted: 27 August 2019

First Online: 27 September 2019

Competing interests

: H.L.: research funding: Takeda, Amgen; Speaker’s Bureau: Takeda, Amgen, Janssen, BMS, Celgene; Consultancy Fees: PharmaMar; S.K.: Consultancy Fees: Takeda; E.G.: Honoraria: Takeda, Janssen, Amgen, BMS; Advisory Board: Takeda, Janssen, Amgen, Novartis; A.P.: Honoraria, Advisory Board: Takeda, Celgene; K.W.: Honoraria: Novartis, Janssen, Celgene, Amgen, Onyx, Takeda, BMS; Consultancy Fees: Janssen, Celgene, Amgen, BMS, Takeda, Onyx; R.G.: Research Funding: Roche, Celgene, Takeda, Novartis; Personal Fees: Roche, Takeda, BMS, Amgen; H.E.: Speaker’s Bureau, Advisory Board: Celgene, Janssen, Amgen, BMS, Novartis; Consultancy Fees, Honoraria: Celgene, Janssen, BMS, Amgen; W.W.: Research Funding: Amgen, BMS, Celgene, Janssen, Novartis, Roche, Takeda; Advisory Board/Consultancy fees: Amgen, BMS, Celgene, Janssen, Novartis, Pfizer, Roche, Sandoz, Takeda; T.M.: Honoraria: Takeda. NZ.: Honoraria: Janssen, Celgene, Takeda, Amgen. The remaining authors declare no competing interests.

: This study has been conducted according to the principles of the declaration of Helsinki 2008. Ethical approval has been granted from all ethical committees responsible for all participating study sites including the ethical committee of the city of Vienna for Austria, the ethical committee of the medical faculty of Leipzig for Germany, and the central ethics committee of the ministry of health for Czech Republic. All patients signed an informed consent for participating in this trial, including the option of publication of the data.

: This work has been supported by a research grant of Takeda.

: The data are available for all study authors. The datasets used and analysed during the current study are available from the corresponding author on reasonable request.