Sugano, Teppei
Masuda, Mari
Takeshita, Fumitaka
Motoi, Noriko http://orcid.org/0000-0001-7098-3311
Hirozane, Toru
Goto, Naoko
Kashimoto, Shigeki
Uno, Yuko
Moriyama, Hideki
Sawa, Masaaki
Nagakawa, Yuichi
Tsuchida, Akihiko
Seike, Masahiro
Gemma, Akihiko
Yamada, Tesshi http://orcid.org/0000-0002-6843-7482
Article History
Received: 1 April 2020
Revised: 17 August 2020
Accepted: 22 October 2020
First Online: 27 November 2020
Ethics approval and consent to participate
: All the animal experimental protocols in this study were reviewed and approved by the institutional ethics and recombination safety committees of the National Cancer Center Research Institute (Tokyo, Japan). Two human NSCLC cell lines, A549 and NCI-H2228, were obtained from the ATCC (Manassas, VA, USA).
: The datasets generated and/or analysed during the present study are not publicly available but may be available from the corresponding author on reasonable request. The miRNA microarray data have been deposited in the NCBIs Gene Expression Omnibus database under the accession number GSE95766.
: The authors declare no competing interests. S.K., Y.U., H.M. and M.S. are employees of Carna Biosciences, Inc. (Kobe, Japan). T.Y. and M.M. have received a research grant from the company. The remaining authors declare no conflict of interest.
: This study was supported by the National Cancer Center Research and Development Fund (26-A-13 and 26-A-5 to T.Y. and 30-A-2 to M.M.), the Acceleration Transformative Research for Medical Innovation (ACT-MS) program of the Japan Agency for Medical Research and Development (AMED) (16im0210804h0001 to T.Y.), the Kobayashi Foundation for Cancer Research (to T.Y.), a KAKENHI Grant-in-Aid for Challenging Exploratory Research (16K14627 to M.M. and 19H05566 to T.Y.), a Grant-in Aid for Scientific Research (B) (17H03603 to M.M.) from the Japan Society for the Promotion of Science (JSPS), a Cancer Research Grant from the Foundation for Promotion of Cancer Research in Japan (to M.M.) and Research Grant from the Princess Takamatsu Cancer Research Fund (to M.M.). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.