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Article History

Received: 26 June 2020

Revised: 31 October 2020

Accepted: 5 November 2020

First Online: 10 December 2020

Ethical approval and consent to participate

: The database was designed as a public health surveillance registry to support rapid clinical decision making, in accordance with the UK Policy Framework for Health and Social Care Research, the UK National Research Ethics Service, and the UK Governance Arrangement for Research Ethic Committees. At an institutional level, this cohort study was approved according to local information governance processes. All patient information was de-identified at source by the treating team, so consent was not required.

: Not applicable.

: All data in the study can be made available at the request of the editors. At the conclusion of the study, we plan to make the data available in a publicly available database.

: The authors declare no competing interests.

: University of Birmingham provided the database and bioinformatics support, G.M. is partially funded by a Cancer Research UK grant (A30259). This paper presents independent research supported by the National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre (Grant Reference Number BRC-1215-20009). The views expressed are those of the author(s) and not necessarily those of the NIHR, Public Health England or the Department of Health and Social Care.