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Article History

Received: 5 February 2020

Revised: 29 September 2020

Accepted: 5 November 2020

First Online: 30 November 2020

Ethics approval and consent to participate

: The human study was approved by the Ethics Committee of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. Written informed consent was obtained from each participant. The study was performed in accordance with the Declaration of Helsinki. Animal care and sacrifice were conducted according to methods approved by the Animal Care and Use Committee, the Center for Animal Experiments of Shanghai Jiao Tong University.

: Not applicable.

: RNA-seq data are available in the Gene Expression Omnibus (GEO) database under accession number GSE136725. All data described in this study are available upon request.

: The authors declare no competing interests.

: This work was supported by the National Key Research and Development Program of China (2018YFA0107802 and 2018YFC0910500), the National Natural Science Foundation of China (81973996 and 81570119), the Joint Funds for the Innovation of Science and Technology of Fujian Province of China (2017Y9005), the Shanghai Municipal Education Commission Gaofeng Clinical Medicine Grant (20161304), the Program of Shanghai Academic/Technology Research Leader (19XD1402500), the Shanghai Municipal Health Commission (2019CXJQ01), and the Collaborative Innovation Center of Hematology.