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Article History

Received: 26 October 2020

Revised: 9 November 2020

Accepted: 17 November 2020

First Online: 16 December 2020

Ethics approval and consent to participate

: Not applicable.

: Not applicable.

: Not applicable.

: N.C. and B.Z. declare no competing interests. L.A.B. has received research funding from AstraZeneca, GenMab, Sierra Oncology and ToleroPharmaceuticals, and has served as an advisor/consultant for AstraZeneca, GenMab, Sierra Oncology, PharmaMar, AbbVie, Bristol-Myers Squibb, Alethia, Merck, Pfizer and Jazz Pharmaceuticals. T.A.Y. has received research support to the institution from Artios, AstraZeneca, Bayer, Clovis, Constellation, Cyteir, Eli Lilly, EMD Serono, Forbius, F-Star, GlaxoSmithKline, Genentech, ImmuneSensor, Ipsen, Jounce, Karyopharm, Kyowa, Merck, Novartis, Pfizer, Ribon Therapeutics, Regeneron, Repare, Sanofi, Scholar Rock, Seattle Genetics, Tesaro and Vertex Pharmaceuticalsre, and has served as a consultant for Almac, Aduro, AstraZeneca, Atrin, Axiom, Bayer, Bristol-Myers Squibb, Calithera, Clovis, Cybrexa, EMD Serono, F-Star, Guidepoint, Ignyta, I-Mab, Jansen, Merck, Pfizer, Repare, Roche, Rubius, Schrodinger, Seattle Genetics, Varian and Zai Labs.

: The authors acknowledge the MD Anderson Cancer Center support grant (P30 CA016672). T.A.Y. is a V Foundation V Clinical Scholar (VC2020-001), which supports a Program of Clinical Trials targeting the DNA damage response (DDR).