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Article History

Received: 2 October 2019

Accepted: 24 February 2020

First Online: 23 March 2020

Ethics approval and consent to participate

: All experiments involving human subjects were performed in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki), and the relevant guidelines and regulations of Soochow University. All experimental protocols were approved by the Research Ethics Committee of the First Affiliated Hospital of Soochow University. With informed consents from all subjects, paired specimens of GC and adjacent normal tissues were collected from patients who underwent surgical resection. None of the patients received anticancer therapy before surgery. Animal experiments complied with the ARRIVE guidelines, and were carried out in accordance with the National Institutes of Health guidelines for the care and use of laboratory animals (NIH Publications No. 8023, revised 1978).

: All pertinent data to support this study are included in the paper and supplementary files. Further data supporting the findings are available upon request.

: The authors declare no competing interests.

: This work was supported by The National Natural Science Foundation of China (NSFC, Nos. 81871952, 81670358 and 81873528), Six talent peaks project in Jiangsu Province (BU24600117), the project for the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and National Center for International Research (2017B01012).