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Article History

Received: 2 December 2019

Revised: 4 April 2020

Accepted: 17 April 2020

First Online: 11 May 2020

Ethics approval and consent to participate

: All experiments were carried out according to Israel regulations on animal experimentation and Weizmann Institute guidelines. All experimental protocols were reviewed and approved by Weizmann Institutional Animal Care and Use Committee (IACUC), and were performed according to Israeli Legislation and Regulation on the Use of Animals in Biological and Medical Research.

: Our paper does not contain any individual person’s data in any form (including individual details, images or videos).

: The data sets used and/or analysed during this study are available from the corresponding author on reasonable request, and most of the original data are included in this paper.

: The authors declare no competing interests.

: This work was supported in part by Israel Science Foundation grants 326/14; The Benoziyo Endowment Fund for the Advancement of Science; European Research Council Advanced grant 232640-IMAGO; the Thompson Foundation; National Institutes of Health grant (R01 CA75334); Michal Neeman is the incumbent of the Helen and Morris Mauerberger Chair in Biological Sciences.