Walsh, Naomi http://orcid.org/0000-0002-2178-3564
Andrieu, Charlotte
O’Donovan, Peter
Quinn, Cecily
Maguire, Alanna
Furney, Simon J. http://orcid.org/0000-0002-8920-6800
Gullo, Giuseppe
Crown, John http://orcid.org/0000-0002-3125-7613
Funding for this research was provided by:
Cancer Clinical Research Trust (CCRT)
Irish Centre for High End Computing and Royal College of Surgeons in Ireland StAR programme and Irish Cancer Society CCRC BREAST-PREDICT
Article History
Received: 28 November 2019
Revised: 16 June 2020
Accepted: 8 July 2020
First Online: 27 July 2020
Ethics approval and consent to participate
: Ethical approval for this study was granted by St. Vincent University Hospital Ethics and Medical Committee, Dublin, Ireland. Informed consent was sought and granted by all exceptional responders for participation in the study. The study was performed in accordance with the Declaration of Helsinki.
: Not applicable.
: Whole-exome sequencing and clinical data from this project is available from EGA (accession number: EGAS00001004486). Archive for academic research within the constraints of the consent given from patients. All bioinformatics tools are fully described in “Methods”.
: The authors declare no competing interests.
: Funding for this study was provided by Cancer Clinical Research Trust (CCRT) (to N.W.). We would like to thank the Irish Centre for High End Computing (ExternalRef removed) for the use of HPC infrastructure. S.J.F. acknowledges support from the Royal College of Surgeons in Ireland StAR programme and the Irish Cancer Society CCRC BREAST-PREDICT (CCRC13GAL). The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript and decision to submit the manuscript for publication.