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Authors
Dunlop, Charles R. https://orcid.org/0000-0002-8194-2598
Wallez, Yann
Johnson, Timothy Isaac
Bernaldo de Quirós Fernández, Sandra
Durant, Stephen T.
Cadogan, Elaine B.
Lau, Alan
Richards, Frances M.
Jodrell, Duncan I. https://orcid.org/0000-0001-9360-1670
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Funding
Funding for this research was provided by:
Cancer Research UK (C14303/A17197, C9545/A29580, C14303/A17197, C9545/A29580, C14303/A17197, C9545/A29580, C14303/A17197, C9545/A29580, C14303/A17197, C9545/A29580, C96/A25238)
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Article History
Received: 25 March 2020
Revised: 1 July 2020
Accepted: 16 July 2020
First Online: 3 August 2020
Ethics approval and consent to participate
: All mouse experiments were carried out in the CRUK-CI BRU, in accordance with the UK Animals (Scientific Procedures) Act 1986, with approval from the CRUK-CI Animal Welfare and Ethical Review Body.
: All original data are archived and stored at the Cancer Research UK Cambridge Institute, Cambridge, UK. Cell lines generated in this study—MIA PaCa-2 ATM-KO (clones B4, B7, C4) and controls—will be made available to other researchers upon request.
: Y.W., S.T.D., E.B.C. and A.L. are employees of AstraZeneca. T.I.J. recently became an employee of Artios Pharma. D.I.J. has received research funding from AstraZeneca for both laboratory research and clinical trial projects.
: C.R.D., Y.W., T.I.J., S.B.d.Q.F., F.M.R. and D.I.J. were funded by Cancer Research UK Institute core grants C14303/A17197 and C9545/A29580. In vivo studies were funded by Cancer Research UK Precision Panc grant C96/A25238. C.R.D. was also a recipient of funding from the Pancreatic Cancer UK Future Research Leaders Fund grant RG81962. The Li Ka Shing Centre in which this research was performed was generously funded by CK Hutchison Holdings Limited, the University of Cambridge, Cancer Research UK, The Atlantic Philanthropies and a range of other projects.
