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Authors
Forker, Laura J. https://orcid.org/0000-0002-6506-0894
Bibby, Becky
Yang, Lingjian
Lane, Brian
Irlam, Joely
Mistry, Hitesh https://orcid.org/0000-0002-9683-1903
Khan, Mairah
Valentine, Helen
Wylie, James
Shenjere, Patrick
Leahy, Michael
Gaunt, Piers
Billingham, Lucinda
Seddon, Beatrice M.
Grimer, Rob
Robinson, Martin
Choudhury, Ananya
West, Catharine https://orcid.org/0000-0002-0839-3449
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Funding
Funding for this research was provided by:
Sarcoma UK (SUK205.2016, SUK205.2016)
Cancer Research UK (CRUK/05/003, C1094/A6786)
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Article History
Received: 25 February 2022
Revised: 9 March 2023
Accepted: 28 March 2023
First Online: 21 April 2023
Competing interests
: The authors declare no competing interests.
: The study had appropriate ethical approval for the use of tissue and anonymised clinical data from each of the four cohorts, including (1) Manchester Cancer Research Centre (MCRC) biobank (<i>n</i> = 34) (18/NW/0092); (2) a single centre Manchester retrospective cohort (<i>n</i> = 165) (06Q1403256); (3) the VORTEX-Biobank cohort (<i>n</i> = 203) (06/MRE03/3, NCT00423618); and (4) an intra-tumour heterogeneity cohort (<i>n</i> = 10 tumours, <i>n</i> = 45 biopsies, 3–8 biopsies/tumour) (06Q1403256). For the MCRC-Biobank and VORTEX-Biobank cohorts, the patients gave written informed consent. For the Manchester retrospective cohort, this was not required by the ethics committee as all clinical data were fully anonymised to the research team. The study was performed in accordance with the Declaration of Helsinki.
: Not applicable.
