Chen, Mingjue
Mashima, Tetsuo
Oishi, Taichi
Muramatsu, Yukiko
Seto, Yosuke
Takamatsu, Manabu
Kawata, Naomi
Morino, Shun
Nakamura, Ayane
Inaba, Saori
Yuan, Xunmei
Maruyama, Kohei
Suzuki, Mai
Sato, Ayana
Yoshida, Haruka
Jang, Myung-Kyu
Mizutani, Anna
Takeuchi, Kengo https://orcid.org/0000-0002-1599-5800
Yamaguchi, Kensei
Shirai, Fumiyuki
Nagayama, Satoshi https://orcid.org/0000-0001-9632-914X
Katayama, Ryohei https://orcid.org/0000-0001-7394-895X
Seimiya, Hiroyuki https://orcid.org/0000-0003-3314-9736
Funding for this research was provided by:
MEXT | Japan Society for the Promotion of Science (19H03523, 22H02931, 18K07337)
Japan Agency for Medical Research and Development (16770857, 19090105, 22580621, 23810633)
Nippon Foundation
Takeda Science Foundation
Article History
Received: 11 December 2022
Revised: 24 October 2023
Accepted: 27 October 2023
First Online: 15 November 2023
Competing interests
: HS received research grants from the Nippon Foundation and Takeda Science Foundation and holds a patent of RK-582 and related chemical compounds. FS holds a patent of RK-582 and related chemical compounds. RK received a research grant from TOPPAN. The other authors declare no competing interests.
: This study was performed in accordance with the Declaration of Helsinki under approval from the Institutional Review Board of Japanese Foundation for Cancer Research (JFCR) (Tokyo, Japan) and the written informed consent of patients. Animal procedures were carried out, following national laws and policies (Guidelines for Proper Conduct of Animal Experiments, Science Council of Japan, 2006) in the animal experiment room at JFCR according to protocols approved by the JFCR Animal Care and Use Committee.