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Article History

Received: 14 July 2023

Revised: 22 November 2023

Accepted: 1 December 2023

First Online: 21 December 2023

Competing interests

: SL – Honoraria: Eisai, Prosigna, Roche, Pfizer, Novartis, Sanofi. Advisory: Shionogi, Sanofi, GLG consulting, Rejuversen, Oxford Biodynamics. Research grant funding: CRUK, NIHR, Against Breast Cancer, Pathios Therapeutics. Travel/Accommodation/Expenses: Pfizer, Roche, Synthon, Piqur Therapeutics. Stock holding: Mitox Therapeutics. Previous employment: Pfizer. My institution has received funding for clinical trials for which I am chief investigator or principal investigator from Cancer Research UK, Boehringer Ingelheim, Piqur Therapeutics, AstraZeneca, Carrick Therapeutics, Sanofi, Merck KGaA, Synthon, Roche, Exscientia, BioInvent, RS Oncology. TM – Consulting agreements: AstraZeneca, Ground Truth Laboratories, Perspectum, Teysuno. Employment: National Cancer Research Institute. PS – Honoraria: AZ. Support to attend conferences/educational events: BMS/Takeda. Advisory roles: BMS/Takeda. MAH – Receives funding from University College London Hospitals Biomedical Research Centre. All other authors—no completing interests to declare.

: Consent for publication was obtained for use of de-identified trial data.

: The study was conducted in accordance with the ethical principles of the International Council for Harmonization guideline for Good Clinical Practice, the Declaration of Helsinki and applicable local regulations. All patients provided written informed consent before any study procedures were performed. The study sites received ethical approval from the South Central Oxford A Ethics Committee(16/SC/0395).